Nagarjun and Rakul landed in Hyderabad after wrapping a month long schedule in Portugal. In the spirit of Manmadhudu, the original which was all fun, the Manmadhudu 2 team kept the fun going everyday. Vennela Kishore, Rao Ramesh, Lakshmi and Jhansi also joined the crew. Post his successful directorial debut, Rahul Ravindran is directing Manmadhudu 2. It is heard that everyday was a laugh riot on set.
Chaitan Bharadwaj is composing music for this film while M Sukumar is handling the cinematography. Nagarjuna and P. Kiran are jointly producing the movie under Manam Enterprises and Anandi Art Creations banners in association with Viacome18 Motion Pictures.